De fleste helsepersonell anbefaler en rekke terapier for kroniske smerter. Av denne grunn har pasienter en tendens til å bruke behandlingene nevnt ovenfor i kombinasjoner som de endrer over tid for å få bedre resultater.Fra et biokjemisk synspunkt har disse medisinene en lignende virkningsmekanisme. De hemmer flere mellomledd som involverer cykl
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